1. The Francis Crick Institute 1 , 1 Midland Way, London NW1 1AT , UK
2. Biomedical Institute for Multimorbidity, Hull York Medical School, University of Hull 2 , Hull HU6 7RX , UK
3. Maternal and Fetal Health Research Centre 3 , Manchester M13 9WL , UK
4. University of Manchester, 3 , Manchester M13 9WL , UK