Affiliation:
1. Université de Nantes, INSERM, CNRS, CRCI2NA 1 , 44000 Nantes , France
2. Équipe Labellisée LIGUE Contre le Cancer CRCI2NA 2 , 44000 Nantes , France
3. Institut de Cancérologie de l'Ouest, 44805 Saint Herblain 3 , France
Abstract
ABSTRACT
Breast cancer stands as the most prevalent malignancy afflicting women. Despite significant advancements in its diagnosis and treatment, breast cancer metastasis continues to be a leading cause of mortality among women. To metastasize, cancer cells face numerous challenges: breaking away from the primary tumor, surviving in the circulation, establishing in a distant location, evading immune detection and, finally, thriving to initiate a new tumor. Each of these sequential steps requires cancer cells to adapt to a myriad of stressors and develop survival mechanisms. In addition, most patients with breast cancer undergo surgical removal of their primary tumor and have various therapeutic interventions designed to eradicate cancer cells. Despite this plethora of attacks and stresses, certain cancer cells not only manage to persist but also proliferate robustly, giving rise to substantial tumors that frequently culminate in the patient's demise. To enhance patient outcomes, there is an imperative need for a deeper understanding of the molecular and cellular mechanisms that empower cancer cells to not only survive but also expand. Herein, we delve into the intrinsic stresses that cancer cells encounter throughout the metastatic journey and the additional stresses induced by therapeutic interventions. We focus on elucidating the remarkable strategies adopted by cancer cells, such as cell–cell clustering and intricate cell–cell communication mechanisms, to ensure their survival.
Funder
Fondation pour la Recherche Médicale
Emerald Foundation, Inc.
Ligue Contre le Cancer
Institut National Du Cancer
SIRIC ILIAD
Publisher
The Company of Biologists
Cited by
2 articles.
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