Abstract
Serotonin uptake receptor (SERT) plays an important role in neural circuit development and reduced SERT function is associated with neurodevelopmental disorders. Now, a paper published in Development finds that SERT acts in a defined developmental time window in the hippocampus in a sex-biased fashion, and its absence from CA3 pyramid neurons leads to defects in neural circuit assembly, electrophysiology and behaviour. We caught up with first author Roberto De Gregorio and corresponding author Ji Sze, an Associate Professor at Albert Einstein College of Medicine, to find out more about their research.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology