Innervation of the developing kidney in vivo and in vitro

Author:

Tarnick Julia1,Elhendawi Mona1,Holland Ian1,Chang Ziyuan1,Davies Jamie A.1ORCID

Affiliation:

1. University of Edinburgh Deanery of Biomedical Science , , Edinburgh EH8 9XD , UK

Abstract

ABSTRACT Within the adult kidney, renal neurites can be observed alongside the arteries where they play a role in regulating blood flow. However, their role and localization during development has so far not been described in detail. In other tissues, such as the skin of developing limb buds, neurons play an important role during arterial differentiation. Here, we aim to investigate whether renal nerves could potentially carry out a similar role during arterial development in the mouse kidney. In order to do so, we used whole-mount immunofluorescence staining to identify whether the timing of neuronal innervation correlates with the recruitment of arterial smooth muscle cells. Our results show that neurites innervate the kidney between day 13.5 and 14.5 of development, arriving after the recruitment of smooth muscle actin-positive cells to the renal arteries.

Funder

Kidney Research UK

Biotechnology and Biological Sciences Research Council

University of Edinburgh

Publisher

The Company of Biologists

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

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