Generation of brain tumours by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen
Author:
Affiliation:
1. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
2. Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Abstract
Funder
The Brain Tumour Charity UK
a Brain Research Trust Fellowship (UCL Institute of Neurology).
Fundação para a Ciência e a Tecnologia - DFRH
UCL Impact PhD studentship
Publisher
The Company of Biologists
Subject
General Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology (miscellaneous),Medicine (miscellaneous),Neuroscience (miscellaneous)
Link
http://journals.biologists.com/dmm/article-pdf/9/2/211/1869429/dmm022715.pdf
Reference51 articles.
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2. Efficient delivery of Cre-recombinase to neurons in vivo and stable transduction of neurons using adeno-associated and lentiviral vectors;Ahmed;BMC Neurosci.,2004
3. Cre-mediated somatic site-specific recombination in mice;Akagi;Nucleic Acids Res.,1997
4. Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: a molecular switch for control of gene expression;Anton;J. Virol.,1995
5. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease;Backman;Nat. Genet.,2001
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