EvoChromo: towards a synthesis of chromatin biology and evolution

Author:

Drinnenberg Ines A.1,Berger Frédéric2ORCID,Elsässer Simon J.3,Andersen Peter R.4ORCID,Ausió Juan5,Bickmore Wendy A.6ORCID,Blackwell Alexander R.7,Erwin Douglas H.8,Gahan James M.9,Gaut Brandon S.10,Harvey Zachary H.11,Henikoff Steven12,Kao Joyce Y.1314,Kurdistani Siavash K.15,Lemos Bernardo16,Levine Mia T.17,Luger Karolin18,Malik Harmit S.12,Martín-Durán José M.19,Peichel Catherine L.20,Renfree Marilyn B.21,Rutowicz Kinga22,Sarkies Peter23ORCID,Schmitz Robert J.24,Technau Ulrich25,Thornton Joseph W.26,Warnecke Tobias23ORCID,Wolfe Kenneth H.27ORCID

Affiliation:

1. Institut Curie, Paris Sciences et Lettres Research University, Centre National de la Recherche Scientifique UMR 3664, Paris 75005, France

2. Gregor Mendel Institute, Austrian Academy of Sciences, Vienna BioCenter, Dr. Bohr-Gasse 3, 1030 Vienna, Austria

3. Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden

4. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC), Dr. Bohrgasse 3, 1030 Vienna, Austria

5. Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, V8W 3P6, Canada

6. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK

7. Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, UK

8. Department of Paleobiology, MRC-121, National Museum of Natural History, Washington, DC 20013-7012, USA

9. Sars Centre for Marine Molecular Biology, University of Bergen, Thormøhlensgt. 55, 5008 Bergen, Norway

10. Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA 92697, USA

11. Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA

12. Division of Basic Sciences and Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

13. Center for Genomics and Systems Biology, New York University, 12 Waverly Place, New York, NY 10003, USA

14. Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zürich, Otto-Stern-Weg 3, 8093 Zürich, Switzerland

15. Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA

16. Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA

17. Department of Biology, Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA

18. Howard Hughes Medical Institute and Department of Biochemistry, CU Boulder, Boulder, CO 80303, USA

19. Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London E1 4NS, UK

20. Institute of Ecology and Evolution, University of Bern, 3012 Bern, Switzerland

21. School of BioSciences, The University of Melbourne, Melbourne, 3010 VIC, Australia

22. Institute of Plant and Microbial Biology, Zurich-Basel Plant Science Center, University of Zurich, 8092 Zürich, Switzerland

23. MRC London Institute of Medical Sciences and Institute of Clinical Sciences, IMperial College London, Du Cane Road, London W12 0NN, UK

24. Department of Genetics, University of Georgia, Athens, GA 30602, USA

25. Department for Molecular Evolution and Development, Centre of Organismal Systems Biology, University of Vienna, Vienna A-1090, Austria

26. Department of Human Genetics, and Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637 USA

27. Conway Institute and School of Medicine, University College Dublin, Dublin 4, Ireland

Abstract

ABSTRACT Over the past few years, interest in chromatin and its evolution has grown. To further advance these interests, we organized a workshop with the support of The Company of Biologists to debate the current state of knowledge regarding the origin and evolution of chromatin. This workshop led to prospective views on the development of a new field of research that we term ‘EvoChromo’. In this short Spotlight article, we define the breadth and expected impact of this new area of scientific inquiry on our understanding of both chromatin and evolution.

Funder

The Company of Biologists

Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung

SCIEX – Scientific Exchange Programme NMS.CH

European Union's 7th Framework

University of Zürich

Julius Klaus Foundation

Centre national de la recherche scientifique

Labex DEEP

IDEX Université de recherche Paris Sciences et Lettres

Institut Curie

European Research Council

Gatsby Charitable Foundation

National Institutes of Health

Norges forskningsråd

University of Bergen

National Science Foundation

Medical Research Council

Fonds zur Förderung der wissenschaftlichen Forschunggrant

Novo Nordisk

W. M. Keck Foundation

National Institute of General Medical Sciences

Howard Hughes Medical Institute

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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