Affiliation:
1. Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871, Japan
Abstract
The cadherin superfamily plays key roles in intercellular adhesion. An emerging intercellular adhesion system, consisting of nectin and afadin, also has roles in organization of a variety of intercellular junctions either in cooperation with, or independently of, cadherin. Nectin is a Ca2+-independent immunoglobulin-like intercellular adhesion molecule, and afadin is a nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. This novel intercellular adhesion system has roles in the organization of E-cadherin-based adherens junctions and claudin-based tight junctions in epithelial cells. The adhesion system is furthermore involved in the formation of synapses in neurons and the organization of heterotypic junctions between Sertoli cells and spermatids in the testis.
Publisher
The Company of Biologists
Reference100 articles.
1. Aberle, H., Schwartz, H. and Kemler, R. (1996). Cadherin-catenin complex: protein interactions and their implications for cadherin function. J. Cell Biochem.61,514-523.
2. Adams, C. L., Chen, Y. T., Smith, S. J. and Nelson, W. J.(1998). Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high resolution tracking of E-cadherin-green fluorescent protein. J. Cell Biol.142,1105-1119.
3. Amaral, D. G. and Dent, J. A. (1981). Development of the mossy fibers of the dentate gyrus: I. A light and electron microscopic study of the mossy fibers and their expansions. J. Comp. Neurol.195,51-86.
4. Anastasiadis, P. Z. and Reynolds, A. B. (2000). The p120 catenin family: complex roles in adhesion, signaling and cancer. J. Cell Sci.113,1319-1334.
5. Andersson, A. M., Edvardsen, K. and Skakkebaek, N. E.(1994). Expression and localization of N- and E-cadherin in the human testis and epididymis. Int. J. Androl.17,174-180.
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