Planar cell polarity in moving cells: think globally, act locally-Reference-Cited by-同舟云学术

Planar cell polarity in moving cells: think globally, act locally

Published:2017-01-15 Issue:2 Volume:144 Page:187-200
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Davey Crystal F.¹,Moens Cecilia B.¹^ORCID

Affiliation:

1. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, B2-159, 1100 Fairview Ave. N., Seattle, WA 98109, USA

Abstract

ABSTRACT The planar cell polarity (PCP) pathway is best known for its role in polarizing epithelial cells within the plane of a tissue but it also plays a role in a range of cell migration events during development. The mechanism by which the PCP pathway polarizes stationary epithelial cells is well characterized, but how PCP signaling functions to regulate more dynamic cell behaviors during directed cell migration is much less understood. Here, we review recent discoveries regarding the localization of PCP proteins in migrating cells and their impact on the cell biology of collective and individual cell migratory behaviors.

Funder

National Institutes of Health

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/144/2/187/1848906/dev122804.pdf

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