Notch destabilises maternal β-catenin and restricts dorsal-anterior development in Xenopus

Author:

Acosta Helena1,López Silvia L.1,Revinski Diego R.1,Carrasco Andrés E.1

Affiliation:

1. Laboratorio de Embriología Molecular, Instituto de Biología Celular y Neurociencias, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, piso 3, 1121 Ciudad Autónoma de Buenos Aires, Argentina

Abstract

The blastula chordin- and noggin-expressing centre (BCNE) is the predecessor of the Spemann-Mangold's organiser and also contains the precursors of the brain. This signalling centre comprises animal-dorsal and marginal-dorsal cells and appears as a consequence of the nuclear accumulation of β-catenin on the dorsal side. Here, we propose a role for Notch that was not previously explored during early development in vertebrates. Notch initially destabilises β-catenin in a process that does not depend on its phosphorylation by GSK3. This is important to restrict the BCNE to its normal extent and to control the size of the brain.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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