Affiliation:
1. Hubrecht Laboratory, Utrecht
Abstract
Experiments in which folds of competent ectoderm were attached to neural plates of host embryos at various cranio-caudal levels (Nieuwkoop et al., 1952) suggested that two successive influences emanate from the underlying archenteron roof: a first one representing a more or less non-specific activation which leads autonomously to a differentiation in a prosencephalic direction; and a second one transforming these prosencephalic differentiation tendencies into more caudal ones leading to the formation of rhombencephalon and spinal cord.
The work of Eyal-Giladi (1954) in which the temporal and spatial relations of neural induction were analysed by means of an interruption of the induction at various stages of development and at various cranio-caudal levels of the presumptive neural area showed very clearly that during gastrulation two successive waves of induction actually pass through the presumptive neuro-ectoderm in a caudo-cranial direction. The first wave, which emanates from the presumptive prechordal material, leads to an activation of the ectoderm and its autonomous development in a prosencephalic direction.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
13 articles.
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