Affiliation:
1. 500 D.W. Brooks Drive, 270 Coverdell Building, Department of Genetics, University of Georgia, Athens, Georgia 30602, USA.
Abstract
The thymus is the primary organ responsible for generating functional T cells in vertebrates. Although T cell differentiation within the thymus has been an area of intense investigation, the study of thymus organogenesis has made slower progress. The past decade, however, has seen a renewed interest in thymus organogenesis, with the aim of understanding how the thymus develops to form a microenvironment that supports T cell maturation and regeneration. This has prompted modern revisits to classical experiments and has driven additional genetic approaches in mice. These studies are making significant progress in identifying the molecular and cellular mechanisms that control specification, early organogenesis and morphogenesis of the thymus.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
212 articles.
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