Crucial roles of Brn1 in distal tubule formation and function in mouse kidney-Reference-Cited by-同舟云学术

Crucial roles of Brn1 in distal tubule formation and function in mouse kidney

Published:2003-10-01 Issue:19 Volume:130 Page:4751-4759
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Nakai Shigeyasu¹²,Sugitani Yoshinobu¹,Sato Hiroshi³,Ito Sadayoshi³,Miura Yukio⁴,Ogawa Masaharu⁵,Nishi Miyuki¹,Jishage Kou-ichi¹,Minowa Osamu¹⁶,Noda Tetsuo¹⁶²

Affiliation:

1. Department of Cell Biology, Japanese Foundation for Cancer Research (JFCR)Cancer Institute, 1-37-1 Kami-Ikebukuro, Toshima-Ku, Tokyo 170-8455,Japan

2. Division of Molecular Genetics, Center for Translational and Advanced Animal Researches on Human Diseases, Tohoku University School of Medicine, Sendai 980-8575, Japan

3. Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University School of Medicine, Sendai 980-8574, Japan

4. Miyagi Insurance Hospital, Sendai 981-1103, Japan

5. Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, Wako,Saitama 351-0198, Japan

6. Mouse Functional Genomics Research Group, RIKEN Genomic Sciences Center,Kanagawa 244-0804, Japan

Abstract

This study identifies a role for the gene for the POU transcription factor Brn1 in distal tubule formation and function in the mammalian kidney. Normal development of Henle's loop (HL), the distal convoluted tubule and the macula densa was severely retarded in Brn1-deficient mice. In particular,elongation and differentiation of the developing HL was affected. In the adult kidney, Brn1 was detected only in the thick ascending limb (TAL) of HL. In addition, the expression of a number of TAL-specific genes was reduced in the Brn1+/- kidney, including Umod,Nkcc2/Slc12a1, Bsnd, Kcnj1 and Ptger3. These results suggest that Brn1 is essential for both the development and function of the nephron in the kidney.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/130/19/4751/1144652/4751.pdf

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