Release from Density-Dependent Inhibition of Growth in the Absence of Cell Locomotion-Reference-Cited by-同舟云学术

Release from Density-Dependent Inhibition of Growth in the Absence of Cell Locomotion

Published:1974-10-01 Issue:1 Volume:16 Page:181-188
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

YARNELL MARGARET M.¹,SCHNEBLI H. P.²

Affiliation:

1. Friedrich Miescher-Institut, Basel, Switzerland; Present address: Abteilung für Krebsforschung, Institut für Pathologische Anatomie, Aussenstation Universität Zürich, Birchstrasse 95, CH-8050 Zürich, Switzerland

2. Friedrich Miescher-Institut, Basel, Switzerland

Abstract

3T3 mouse fibroblasts are released from density-dependent inhibition of growth by treatment with insulin. The same insulin treatment stimulates cell locomotion several hours before any new mitoses become visible. Inhibition of cell locomotion by colcemid does not affect the overgrowth stimulation due to insulin. From this it is concluded that cellular locomotion is not a prerequisite for the release from density-dependent inhibition of growth.

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/16/1/181/1419981/181.pdf

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