Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum

Author:

Li Guochun12,Foote Christopher1,Alexander Stephen,Alexander Hannah3

Affiliation:

1. Present address: Department of Biology, University of California, San Diego, LaJolla, CA 92093-0568, USA

2. These authors contributed equally to this study

3. Division of Biological Sciences, University of Missouri, Columbia, MO 65211-7400, USA

Abstract

Sphingosine-1-phosphate, a product of sphingomyelin degradation, is an important element of signal transduction pathways that regulate cell proliferation and cell death. We have demonstrated additional roles for sphingosine-1-phosphate in growth and multicellular development. The specific disruption in Dictyostelium discoideum of the sphingosine-1-phosphate lyase gene, which encodes the enzyme that catalyzes sphingosine-1-phosphate degradation, results in a mutant strain with aberrant morphogenesis, as well as an increase in viability during stationary phase. The absence of sphingosine-1-phosphate lyase affects multiple stages throughout development, including the cytoskeletal architecture of aggregating cells, the ability to form migrating slugs, and the control of cell type-specific gene expression and terminal spore differentiation. This pleiotropic effect, which is due to the loss of sphingosine-1-phosphate lyase, establishes sphingolipids as pivotal regulatory molecules in a wide range of processes in multicellular development.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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