Fgf/MAPK signalling is a crucial positional cue in somite boundary formation-Reference-Cited by-同舟云学术

Fgf/MAPK signalling is a crucial positional cue in somite boundary formation

Published:2001-12-01 Issue:23 Volume:128 Page:4873-4880
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Sawada Atsushi¹²,Shinya Minori¹²,Jiang Yun-Jin³,Kawakami Atsushi¹,Kuroiwa Atsushi²,Takeda Hiroyuki¹

Affiliation:

1. Division of Early Embryogenesis, National Institute of Genetics, Mishima, 411-8540 Japan

2. Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan

3. Vertebrate Development Laboratory, Imperial Cancer Research Fund, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK

Abstract

The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/128/23/4873/1138316/4873.pdf

Reference37 articles.

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