A directional Wnt/β-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in theXenopusretina
Author:
Agathocleous Michalis1, Iordanova Ilina1, Willardsen Minde I.2, Xue Xiao Yan1, Vetter Monica L.2, Harris William A.1, Moore Kathryn B.2
Affiliation:
1. Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. 2. Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA.
Abstract
Progenitor cells in the central nervous system must leave the cell cycle to become neurons and glia, but the signals that coordinate this transition remain largely unknown. We previously found that Wnt signaling, acting through Sox2, promotes neural competence in the Xenopus retina by activating proneural gene expression. We now report that Wnt and Sox2 inhibit neural differentiation through Notch activation. Independently of Sox2, Wnt stimulates retinal progenitor proliferation and this, when combined with the block on differentiation, maintains retinal progenitor fates. Feedback inhibition by Sox2 on Wnt signaling and by the proneural transcription factors on Sox2 mean that each element of the core pathway activates the next element and inhibits the previous one, providing a directional network that ensures retinal cells make the transition from progenitors to neurons and glia.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Reference95 articles.
1. Baker, J. C., Beddington, R. S. and Harland, R. M.(1999). Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev.13,3149-3159. 2. Bani-Yaghoub, M., Tremblay, R. G., Lei, J. X., Zhang, D.,Zurakowski, B., Sandhu, J. K., Smith, B., Ribecco-Lutkiewicz, M., Kennedy, J.,Walker, P. R. et al. (2006). Role of Sox2 in the development of the mouse neocortex. Dev. Biol.295, 52-66. 3. Blackshaw, S., Harpavat, S., Trimarchi, J., Cai, L., Huang, H.,Kuo, W. P., Weber, G., Lee, K., Fraioli, R. E., Cho, S. H. et al.(2004). Genomic analysis of mouse retinal development. PLoS Biol.2,E247. 4. Bunt-Milam, A. H. and Saari, J. C. (1983). Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina. J. Cell Biol.97,703-712. 5. Burns, C. J., Zhang, J., Brown, E. C., Van Bibber, A. M., Van Es, J., Clevers, H., Ishikawa, T. O., Taketo, M. M., Vetter, M. L. and Fuhrmann, S. (2008). Investigation of Frizzled-5 during embryonic neural development in mouse. Dev. Dyn.237,1614-1626.
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