ER-phagy at a glance

Author:

Grumati Paolo1,Dikic Ivan12ORCID,Stolz Alexandra2

Affiliation:

1. Institute of Biochemistry II, Goethe University Frankfurt - Medical Faculty, University Hospital, 60590 Frankfurt am Main, Germany

2. Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt – Riedberg Campus, 60438 Frankfurt am Main, Germany

Abstract

ABSTRACT Selective autophagy represents the major quality control mechanism that ensures proper turnover of exhausted or harmful organelles, among them the endoplasmic reticulum (ER), which is fragmented and delivered to the lysosome for degradation via a specific type of autophagy called ER-phagy. The recent discovery of ER-resident proteins that bind to mammalian Atg8 proteins has revealed that the selective elimination of ER involves different receptors that are specific for different ER subdomains or ER stresses. FAM134B (also known as RETREG1) and RTN3 are reticulon-type proteins that are able to remodel the ER network and ensure the basal membrane turnover. SEC62 and CCPG1 are transmembrane ER receptors that function in response to ER stress signals. This task sharing reflects the complexity of the ER in terms of biological functions and morphology. In this Cell Science at a Glance article and the accompanying poster, we summarize the most recent findings about ER-phagy in yeast and in mammalian cells.

Funder

Deutsche Forschungsgemeinschaft

European Research Council

Publisher

The Company of Biologists

Subject

Cell Biology

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