Autophagy in stem cells: repair, remodelling and metabolic reprogramming

Author:

Boya Patricia1ORCID,Codogno Patrice2ORCID,Rodriguez-Muela Natalia1ORCID

Affiliation:

1. Department of Cellular and Molecular Biology, Centro de Investigaciones Biológicas, CSIC, Madrid, Spain

2. Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, Université Paris-Descartes, Sorbonne Paris Cité, Paris, France

Abstract

ABSTRACT Autophagy is a catabolic pathway by which cellular components are delivered to the lysosome for degradation and recycling. Autophagy serves as a crucial intracellular quality control and repair mechanism but is also involved in cell remodelling during development and cell differentiation. In addition, mitophagy, the process by which damaged mitochondria undergo autophagy, has emerged as key regulator of cell metabolism. In recent years, a number of studies have revealed roles for autophagy and mitophagy in the regulation of stem cells, which represent the origin for all tissues during embryonic and postnatal development, and contribute to tissue homeostasis and repair throughout adult life. Here, we review these studies, focussing on the latest evidence that supports the quality control, remodelling and metabolic functions of autophagy during the activation, self-renewal and differentiation of embryonic, adult and cancer stem cells.

Funder

Ministerio de Economía y Competitividad

European Cooperation in Science and Technology

Muscular Dystrophy Association

Institut National de la Santé et de la Recherche Médicale

Centre National de la Recherche Scientifique

Université Paris Descartes

Institut National Du Cancer

Agence Nationale de la Recherche

Horizon 2020

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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