Affiliation:
1. Epigenetics of Stem Cells, Department of Developmental and Stem Cell Biology, Institut Pasteur, CNRS UMR3738, 25 rue du Docteur Roux, 75015 Paris, France
Abstract
The changes imposed on the nucleus, chromatin and its regulators during mitosis lead to the dismantlement of most gene regulatory processes. However, an increasing number of transcriptional regulators are being identified as capable of binding their genomic targets during mitosis. These so-called ‘mitotic bookmarking factors’ encompass transcription factors and chromatin modifiers that are believed to convey gene regulatory information from mother to daughter cells. In this Primer, we review mitotic bookmarking processes in development and stem cells and discuss the interest and potential importance of this concept with regard to epigenetic regulation and cell fate transitions involving cellular proliferation.
Funder
Institut Pasteur
Centre National de la Recherche Scientifique
Agence Nationale de la Recherche
Fondation ARC pour la Recherche sur le Cancer
Fondation Schlumberger pour l'Education et la Recherche
European Molecular Biology Organization
Marie-Curie Actions
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
84 articles.
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