MEIS transcription factors in development and disease-Reference-Cited by-同舟云学术

MEIS transcription factors in development and disease

Published:2019-08-15 Issue:16 Volume:146 Page:
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Schulte Dorothea¹^ORCID,Geerts Dirk²^ORCID

Affiliation:

1. Institute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, 60528 Frankfurt, Germany

2. Department of Medical Biology L2-109, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands

Abstract

ABSTRACT MEIS transcription factors are key regulators of embryonic development and cancer. Research on MEIS genes in the embryo and in stem cell systems has revealed novel and surprising mechanisms by which these proteins control gene expression. This Primer summarizes recent findings about MEIS protein activity and regulation in development, and discusses new insights into the role of MEIS genes in disease, focusing on the pathogenesis of solid cancers.

Funder

European Cooperation in Science and Technology

Deutsche Forschungsgemeinschaft

KWF Kankerbestrijding

Wilhelm Sander-Stiftung

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.174706/1966713/dev174706.pdf

Reference168 articles.