Divergent G-protein selectivity across melanopsins from mice and humans
Author:
Affiliation:
1. Centre for Biological Timing, Division of Neuroscience and Experimental Psychology, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, UK
Abstract
Funder
Human Frontier Science Program
Medical Research Council
Wellcome Trust
Engineering and Physical Sciences Research Council
Fight for Sight
University of Manchester
Publisher
The Company of Biologists
Subject
Cell Biology
Link
https://journals.biologists.com/jcs/article-pdf/doi/10.1242/jcs.258474/2135995/jcs258474.pdf
Reference34 articles.
1. Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions;Aranda;Cell. Mol. Life Sci,2020
2. Human melanopsin forms a pigment maximally sensitive to blue light (max 479 nm) supporting activation of Gq/11 and Gi/o signalling cascades;Bailes;Proc. R. Soc. B Biol. Sci.,2013
3. Optogenetic activation of Gq signalling modulates pacemaker activity of cardiomyocytes;Beiert;Cardiovasc. Res.,2014
4. Transcriptomic signatures of postnatal and adult intrinsically photosensitive ganglion cells;Berg;eNeuro,2019
5. Loss of gq/11 genes does not abolish melanopsin phototransduction;Chew;PloS ONE
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