Affiliation:
1. Department of Biological Science, College of Engineering and Natural Sciences, The University of Tulsa, Tulsa, OK 74104, USA
Abstract
ABSTRACT
Fertilization is a key biological process in which the egg and sperm must recognize one another and fuse to form a zygote. Although the process is a continuum, mammalian fertilization has been studied as a sequence of steps: sperm bind and penetrate through the zona pellucida of the egg, adhere to the egg plasma membrane and finally fuse with the egg. Following fusion, effective blocks to polyspermy ensure monospermic fertilization. Here, we review how recent advances obtained using genetically modified mouse lines bring new insights into the molecular mechanisms regulating mammalian fertilization. We discuss models for these processes and we include studies showing that these mechanisms may be conserved across different mammalian species.
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
37 articles.
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