Thebric à braclocus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development inDrosophila-Reference-Cited by-同舟云学术

Thebric à braclocus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development inDrosophila

Published:2002-05-15 Issue:10 Volume:129 Page:2419-2433
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Couderc Jean-Louis¹²,Godt Dorothea³²,Zollman Susan⁴,Chen Jiong⁴,Li Michelle³,Tiong Stanley⁵,Cramton Sarah E.⁴,Sahut-Barnola Isabelle¹,Laski Frank A.⁴

Affiliation:

1. INSERM UMR 384, Laboratoire de Biochimie, 28 place Henri Dunant, 63001 Clermont-Ferrand, Cedex, France

2. These authors contributed equally to this work

3. Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada

4. Department of Molecular, Cell, and Developmental Biology and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA

5. Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2E9, Canada

Abstract

The bric à brac (bab) locus acts as a homeotic and morphogenetic regulator in the development of ovaries, appendages and the abdomen. It consists of two structurally and functionally related genes, bab1 and bab2, each of which encodes a single nuclear protein. Bab1 and Bab2 have two conserved domains in common, a BTB/POZ domain and a Psq domain, a motif that characterizes a subfamily of BTB/POZ domain proteins in Drosophila. The tissue distribution of Bab1 and Bab2 overlaps, with Bab1 being expressed in a subpattern of Bab2. Analysis of a series of mutations indicates that the two bab genes have synergistic, distinct and redundant functions during imaginal development. Interestingly, several reproduction-related traits that are sexually dimorphic or show diversity among Drosophila species are highly sensitive to changes in the bab gene dose, suggesting that alterations in bab activity may contribute to evolutionary modification of sex-related morphology.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/129/10/2419/1138983/2419.pdf

Reference82 articles.

1. Ahmad, K. F., Engel, C. K. and Privé, G. G. (1998). Crystal structure of the BTB domain from PLZF. Proc. Natl. Acad. Sci. USA95, 12123-12128.

2. Arnqvist, G. (1998). Comparative evidence for the evolution of genitalia by sexual selection. Nature393, 784-786.

3. Ashburner, M. (1989). Drosophila: A Laboratory Handbook. New York: Cold Spring Harbor Laboratory Press.

4. Bardwell, V. J. and Treisman, R. (1994). The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 8, 1664-1677.

5. Bock, I. R. and Wheeler, M. R. (1972). The Drosophila melanogaster species group. Studies Genet. VII. Univ Texas Publ.7213, 1-102.

Cited by 64 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Drosophila melanogasterpigmentation demonstrates adaptive phenotypic parallelism but genomic unpredictability over multiple timescales;2024-08-10

2. A genetic screen of transcription factors in the Drosophila melanogaster abdomen identifies novel pigmentation genes;G3: Genes, Genomes, Genetics;2024-05-31

3. Genetic basis of variation in thermal developmental plasticity for Drosophila melanogaster body pigmentation;Molecular Ecology;2024-02-16

4. A meta-analysis of butterfly structural colors: their color range, distribution and biological production;Journal of Experimental Biology;2023-11-01

5. The frequency and differential pleiotropy of phenotypic nonspecificity in Drosophila melanogaster;GENETICS;2023-03-31