Effect of high altitude and in vivo adenosine/(β)-adrenergic receptor blockade on ATP and 2,3BPG concentrations in red blood cells of avian embryos

Author:

Dragon S.1,Carey C.1,Martin K.1,Baumann R.1

Affiliation:

1. University of Regensburg, Department of Physiology, Germany, University of Colorado, Department of EPO Biology, Boulder, CO 80309, USA and Canadian Wildlife Service, Rural Route 1, Delta, British Columbia, Canada, V4K 3N2. Stefanie.dragon@vkl.

Abstract

In chick embryos, developmental changes of the blood oxygen tension control hemoglobin (Hb) oxygen affinity via modulation of ATP and 2, 3BPG concentrations in red blood cells. Hypoxia, which is a normal developmental condition for late chick embryos, causes a decrease of the red cell ATP concentration (and increase of red cell oxygen affinity) as well as activation of 2,3BPG synthesis via cyclic AMP-dependent signaling. Adenosine and catecholamines have been implicated as signaling substances in these red cell responses. To assess the extent to which adenosine and catecholamines are involved in vivo in the control of red cell ATP/2,3BPG concentrations, day 13 chick embryos were treated for 24 h with adenosine A(2) and/or (β)-adrenergic receptor blockers and red cell ATP and 2,3BPG levels were determined. The data suggest that adaptive effects later in development in chick embryos induced by adenosine and catecholamines are vital. We have also tested whether avian embryos of the free-living, high-altitude, native white-tailed ptarmigan (Lagopus leucurus) alter their organic phosphate pattern in red cells in response to incubation at different altitudes. Embryos incubated at 3600–4100 m decrease their red cell ATP concentration much more rapidly than embryos of the same clutch incubated at 1600 m. From these data it can be inferred that the oxygen affinity of high altitude embryos will be adjusted to the altitude at which the eggs are incubated.

Publisher

The Company of Biologists

Subject

Insect Science,Molecular Biology,Animal Science and Zoology,Aquatic Science,Physiology,Ecology, Evolution, Behavior and Systematics

Reference21 articles.

1. Phosphate compounds in red cells of the chicken and duck embryo and hatchling;Bartlett;Comp. Biochem. Physiol. A,1976

2. Hypoxic incubation leads to concerted changes in carbonic anhydrase activity and 2,3DPG concentration of chick embryo red cells;Baumann;Dev. Biol,1986

3. Blood oxygen transport in the early avian embryo;Baumann;Physiol. Rev,1992

4. Effects of hypoxia on oxygen afffinity, hemoglobin pattern and blood volume of early chicken embryos;Baumann;Am. J. Physiol,1983

5. Oxygen transport during progressive hypoxia in high altitude and sea-level water fowl;Black;Respir. Physiol,1980

Cited by 11 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3