Affiliation:
1. Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA
Abstract
Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of the Drosophila wing imaginal disc that produces Hh and is near the tracheal air sac primordium (ASP) and myoblasts. Hh distributes in concentration gradients in the anterior compartment of the wing disc, ASP, and myoblasts, and activates genes in each tissue. Some targets of Hh signal transduction are common to the disc, ASP, and myoblasts, whereas others are tissue-specific. Signaling in the three tissues is cytoneme-mediated and cytoneme-dependent. Some ASP cells project cytonemes that receive both Hh and Branchless (Bnl, a Drosophila FGF), and some targets regulated by Hh signaling in the ASP are also dependent on Bnl signal transduction. We conclude that the single source of Hh in the wing disc regulates cell type-specific responses in three discreet target tissues.
Funder
Office of Extramural Research, National Institutes of Health
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
10 articles.
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