NATs at a glance

Author:

Aksnes Henriette1ORCID,McTiernan Nina1ORCID,Arnesen Thomas123ORCID

Affiliation:

1. University of Bergen 1 Department of Biomedicine , , 5009 Bergen , Norway

2. University of Bergen 2 Department of Biological Sciences , , 5009 Bergen , Norway

3. Haukeland University Hospital 3 Department of Surgery , , 5009 Bergen , Norway

Abstract

ABSTRACT Most proteins receive an acetyl group at the N terminus while in their nascency as the result of modification by co-translationally acting N-terminal acetyltransferases (NATs). The N-terminal acetyl group can influence several aspects of protein functionality. From studies of NAT-lacking cells, it is evident that several cellular processes are affected by this modification. More recently, an increasing number of genetic cases have demonstrated that N-terminal acetylation has crucial roles in human physiology and pathology. In this Cell Science at a Glance and the accompanying poster, we provide an overview of the human NAT enzymes and their properties, substrate coverage, cellular roles and connections to human disease.

Funder

Norges Forskningsråd

European Research Council

Horizon 2020

Publisher

The Company of Biologists

Subject

Cell Biology

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