Affiliation:
1. UT Southwestern Medical Center , 5323 Harry Hines Blvd, MC9040 ND13.214, Dallas, TX 75390 , USA
Abstract
ABSTRACT
Cellular quiescence is a dormant, non-dividing cell state characterized by significant shifts in physiology and metabolism. Quiescence plays essential roles in a wide variety of biological processes, ranging from microbial sporulation to human reproduction and wound repair. Moreover, when the regulation of quiescence is disrupted, it can drive cancer growth and compromise tissue regeneration after injury. In this Review, we examine the dynamic changes in metabolism that drive and support dormant and transiently quiescent cells, including spores, oocytes and adult stem cells. We begin by defining quiescent cells and discussing their roles in key biological processes. We then examine metabolic factors that influence cellular quiescence in both healthy and disease contexts, and how these could be leveraged in the treatment of cancer.
Funder
National Institutes of Health
National Institute on Aging
Welch Foundation
W.W. Caruth Jr Foundation
University of Texas Southwestern Medical Center
Publisher
The Company of Biologists
Cited by
1 articles.
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