Affiliation:
1. Eötvös Loránd University 1 , Department of Anatomy, Cell and Developmental Biology, Budapest, 1117 , Hungary
2. Biological Research Centre, Institute of Genetics 2 , Szeged, 6726 , Hungary
Abstract
ABSTRACT
In specialized secretory cells that produce and release biologically active substances in a regulated fashion, tight control of both the quantity and quality of secretory material is of paramount importance. During crinophagy, abnormal, excess or obsolete secretory granules directly fuse with lysosomes to yield crinosomes, in which the delivered secretory material is degraded. Crinophagy maintains the proper intracellular pool of secretory granules, and it is enhanced when secretory material accumulates because of compromised secretion. Recent studies highlight that it can even degrade newly formed, nascent secretory granules that shed from the trans-Golgi network. This implies that crinophagy provides a quality control checkpoint acting at the formation of secretory vesicles, and this degradation mechanism might survey secretory granules throughout their maturation. Of note, a plethora of human disorders is associated with defective lysosomal clearance of secretory material via crinophagy or similar pathways, including macro- or micro-autophagic degradation of secretory granules (referred to here as macro- and micro-secretophagy, respectively). In our Review, we summarize key recent advances in this field and discuss potential links with disease.
Funder
National Research, Development and Innovation Office
Eötvös Loránd Research Network
Magyar Tudományos Akadémia
Publisher
The Company of Biologists
Cited by
3 articles.
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