Affiliation:
1. Sub-Department of Chemical Microbiology, Department of Biochemistry, University of Cambridge, Cambridge, England
Abstract
The reduction in cell surface charge density during the early stages of differentiation of the cellular slime mould, Dictyostelium discoideum, has been studied by the technique of cell electrophoresis. Using specific chemical reagents, it was shown that the cell surface negative charge was probably due to side chain carboxyl groups of proteins. During differentiation, there was a decrease in the density of these groups, accompanied by an increase in that of amino groups. The significance of this finding is discussed in relation to cell surface structure and cell differentiation.
Publisher
The Company of Biologists
Cited by
13 articles.
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