The regulation of TGFβ signal transduction-Reference-Cited by-同舟云学术

The regulation of TGFβ signal transduction

Published:2009-11-15 Issue:22 Volume:136 Page:3699-3714
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Moustakas Aristidis¹,Heldin Carl-Henrik¹

Affiliation:

1. Ludwig Institute for Cancer Research, Uppsala University, BMC, Box 595,SE-75124 Uppsala, Sweden.

Abstract

Transforming growth factor β (TGFβ) pathways are implicated in metazoan development, adult homeostasis and disease. TGFβ ligands signal via receptor serine/threonine kinases that phosphorylate, and activate,intracellular Smad effectors as well as other signaling proteins. Oligomeric Smad complexes associate with chromatin and regulate transcription, defining the biological response of a cell to TGFβ family members. Signaling is modulated by negative-feedback regulation via inhibitory Smads. We review here the mechanisms of TGFβ signal transduction in metazoans and emphasize events crucial for embryonic development.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/136/22/3699/1568755/3699.pdf

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