Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment
Author:
Affiliation:
1. Keratinocyte Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, UK
2. Pfizer Global Research and Development, Sandwich CT13 9NJ, UK
3. Present address: Institute for Genetics, University of Cologne, Cologne D-50674, Germany
Abstract
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Link
http://journals.biologists.com/dev/article-pdf/130/12/2793/1142989/2793.pdf
Reference75 articles.
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2. Arnold, I. and Watt, F. M. (2001). c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr. Biol. 11,558-568.
3. Barone, M. V. and Courtneidge, S. A. (1995). Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. Nature378,509-512.
4. Barr, L. F., Campbell, S. E., Bochner, B. S. and Dang, C. V.(1998). Association of the decreased expression of alpha3beta1 integrin with the altered cell, environmental interactions and enhanced soft agar cloning ability of c-myc-overexpressing small cell lung cancer cells. Cancer Res.58,5537-5545.
5. Bello-Fernandez, C., Packham, G. and Cleveland, J. L.(1993). The ornithine decarboxylase gene is a transcriptional target of c-Myc. Proc. Natl. Acad. Sci. USA90,7804-7808.
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