Synthesis and Transport of Agrin—Like Molecules in Motor Neurons

Abstract

Several lies of evidence indicate that agrin, or a protein very similar to it, directs the formation and maintenance of the postsynaptic apparatus at the neuromuscular junction. We discuss the results of studies involving immunohistochemical, biochemical and in situ hybridization techniques that support hypothesis that agrin or agrin—like molecules active at the junction are produced bymotor neurons.