Establishing neuronal diversity in the spinal cord: a time and a place

Author:

Sagner Andreas1ORCID,Briscoe James1ORCID

Affiliation:

1. The Francis Crick Institute, London NW1 1AT, UK

Abstract

ABSTRACT The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types arranged in characteristic positions. During development, these different types of neurons differentiate from transcriptionally distinct neural progenitors that are arrayed in discrete domains along the dorsal-ventral and anterior-posterior axes of the embryonic spinal cord. This organization arises in response to morphogen gradients acting upstream of a gene regulatory network, the architecture of which determines the spatial and temporal pattern of gene expression. In recent years, substantial progress has been made in deciphering the regulatory network that underlies the specification of distinct progenitor and neuronal cell identities. In this Review, we outline how distinct neuronal cell identities are established in response to spatial and temporal patterning systems, and outline novel experimental approaches to study the emergence and function of neuronal diversity in the spinal cord.

Funder

Cancer Research UK

Medical Research Council

Wellcome Trust

European Research Council

Human Frontier Science Program

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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