Oxygen-sensing mechanisms in development and tissue repair-Reference-Cited by-同舟云学术

Oxygen-sensing mechanisms in development and tissue repair

Published:2021-12-01 Issue:23 Volume:148 Page:
ISSN:0950-1991
Container-title:Development
language:en
Short-container-title:

Author:

Jiang Yida¹,Duan Li-Juan¹,Fong Guo-Hua¹²^ORCID

Affiliation:

1. Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT 06030, USA

2. Department of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA

Abstract

ABSTRACT Under normoxia, hypoxia inducible factor (HIF) α subunits are hydroxylated by PHDs (prolyl hydroxylase domain proteins) and subsequently undergo polyubiquitylation and degradation. Normal embryogenesis occurs under hypoxia, which suppresses PHD activities and allows HIFα to stabilize and regulate development. In this Primer, we explain molecular mechanisms of the oxygen-sensing pathway, summarize HIF-regulated downstream events, discuss loss-of-function phenotypes primarily in mouse development, and highlight clinical relevance to angiogenesis and tissue repair.

Funder

National Institutes of Health

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

https://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.200030/2122310/dev200030.pdf

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