Amplification and Overexpression of the EGF Receptor Gene in Primary Human Glioblastomas-Reference-Cited by-同舟云学术

Amplification and Overexpression of the EGF Receptor Gene in Primary Human Glioblastomas

Published:1985-02-01 Issue:Supplement_3 Volume:1985 Page:161-172
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

LIBERMANN TOWIA A.¹,NUSBAUM HARRIS R.¹,RAZON NISSIM²,KRIS RICHARD¹,LAX IRIT¹,SOREQ HERMONA³,WHITTLE NIGEL⁴,WATERFIELD MICHAEL D.⁴,ULLRICH AXEL⁵,SCHLESSINGER JOSEPH¹

Affiliation:

1. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

2. Department of Neurosurgery, Ichilov Hospital, Tel Aviv Medical Center, Tel Aviv, Israel

3. Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel

4. Protein Chemistry Laboratory, Imperial Cancer Research Fund, Lincoln’s Inn Fields, London WC2A 3PX, U.K.

5. Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California 94080, U.S.A.

Abstract

SUMMARY The expression of epidermal growth factor (EGF) receptor in brain tumours of glial origin was studied at the protein, mRNA and genomic levels. Four out of 10 glioblastomas that overexpress EGF receptor also have gene amplification. The amplified genes appear to be rearranged, generating an aberrant mRNA in at least one of these tumours. Such receptor defects may be relevant to tumorigenesis of human glioblastomas.

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/1985/Supplement_3/161/1422574/joces_s3_0161.pdf

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