The genetics of Pak-Reference-Cited by-同舟云学术

The genetics of Pak

Published:2004-09-01 Issue:19 Volume:117 Page:4343-4354
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

Hofmann Clemens¹,Shepelev Mikhail²,Chernoff Jonathan¹

Affiliation:

1. Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA

2. Russian State Medical University, 1 Ostrovitjanova Street, Moscow, 117997, Russia

Abstract

p21-activated kinases (Paks) are a highly conserved family of enzymes that bind to and are activated by small GTPases of the Cdc42 and Rac families. With the notable exception of plants, nearly all eukaryotes encode one or more Pak genes, indicating an ancient origin and important function for this family of enzymes. Genetic approaches in many different experimental systems, ranging from yeast to mice, are beginning to decipher the different functions of Paks. Although some of these functions are unique to a given organism, certain common themes have emerged, such as the activation of mitogen-activated protein kinase (MAPK) cascades and the regulation of cytoskeletal structure through effects on the actin and tubulin cytoskeletons.

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/117/19/4343/1531827/4343.pdf

Reference113 articles.

1. Abo, A., Qu, J., Cammarano, M. S., Dan, C., Fritsch, A., Baud, V., Belisle, B. and Minden, A. (1998). PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia. EMBO J.17, 6527-6540.

2. Allen, K. M., Gleeson, J. G., Bagrodia, S., Partington, M. W., MacMillan, J. C., Cerione, R. A., Mulley, J. C. and Walsh, C. A. (1998). PAK3 mutation in nonsyndromic X-linked mental retardation. Nat. Genet.20, 25-30.

3. Ang, L. H., Kim, J., Stepensky, V. and Hing, H. (2003). Dock and Pak regulate olfactory axon pathfinding in Drosophila.Development130, 1307-1316.

4. Bagrodia, S., Derijard, B., Davis, R. J. and Cerione, R. A. (1995). Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem.270, 27995-27998.

5. Barac, A., Basile, J., Vazquez-Prado, J., Gao, Y., Zheng, Y. and Gutkind, J. S. (2004). Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor. J. Biol. Chem.279, 6182-6189.

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