On mammary stem cells-Reference-Cited by-同舟云学术

On mammary stem cells

Published:2005-08-15 Issue:16 Volume:118 Page:3585-3594
ISSN:1477-9137
Container-title:Journal of Cell Science
language:en
Short-container-title:

Author:

Woodward Wendy A.¹,Chen Mercy S.²,Behbod Fariba²,Rosen Jeffrey M.²

Affiliation:

1. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-3498, USA

2. Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Place, M638a DeBakey, Houston, TX 77030, USA

Abstract

Mammary gland stem cells are a quiescent and self-renewing population within the mammary gland that are capable of giving rise to the differentiated ductal, alveolar and myoepithelial cells. To identify mammary gland stem cells, several investigators have employed a variety of methods including: non-adherent mammosphere cultures; 5-bromo-2-deoxy-uridine (BrdU) label-retention studies; cell-surface markers, such as Sca1 and CD49f; and Hoechst dye efflux. These methods have helped identify and further characterize signal transduction pathways such as the Notch, Wnt and Hedgehog pathways that may be important for the self-renewal and fate determination of mammary gland stem cells. Stem cells within the mammary gland have been proposed to underpin many types of breast cancer. A better understanding of the signal transduction pathways and the molecules that are responsible for the self-renewal and survival of these cells will be essential in the design of more effective therapies aimed at the eradication of both cancer-initiating cells and breast cancer stem cells.

Publisher

The Company of Biologists

Subject

Cell Biology

Link

http://journals.biologists.com/jcs/article-pdf/118/16/3585/1365964/3585.pdf

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