Towards stem cell based therapies for Parkinson's disease-Reference-Cited by-同舟云学术

Towards stem cell based therapies for Parkinson's disease

Published:2018-01-01 Issue:1 Volume:145 Page:
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Parmar Malin¹^ORCID

Affiliation:

1. Department of Experimental Medical Science, Wallenberg Neuroscience Center, Division of Neurobiology and Lund Stem Cell Center, Lund University, BMC A11, S-221 84 Lund, Sweden

Abstract

ABSTRACT Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson's disease. However, the use of fetal tissue is problematic in terms of low availability and high variability, and it is also associated with ethical concerns that vary between countries. For decades, the field has therefore investigated new scalable source of therapeutic cells from stem cells or via reprogramming. Now it is possible to generate authentic midbrain dopaminergic neurons from pluripotent stem cells and clinical trials using such cells are rapidly approaching.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/doi/10.1242/dev.156117/1852545/dev156117.pdf

Reference29 articles.

1. Cell-based therapies for Parkinson disease-past insights and future potential;Barker;Nat. Rev. Neurol.,2015

2. Human trials of stem cell-derived dopamine neurons for Parkinson's disease: dawn of a new era;Barker;Cell Stem Cell,2017

3. Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors;Bonilla;Glia,2008

4. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts;Caiazzo;Nature,2011

5. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid;Cooper;Mol. Cell. Neurosci.,2010

Cited by 64 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Neuro-regeneration or Repair: Cell Therapy of Neurological Disorders as A Way Forward;Current Neuropharmacology;2024-12

2. Histone Lysine Demethylase KDM5 Inhibitor CPI-455 Induces Astrocytogenesis in Neural Stem Cells;ACS Chemical Neuroscience;2024-03-19

3. Stem Cell-Based Approaches in Parkinson’s Disease Research;International Journal of Stem Cells;2024-03-07

4. Neural Stem Cells in Tissue Engineering;Stem Cells in Clinical Application and Productization;2024-02-21

5. Stem Cell-Based Therapy for Parkinson’s Disease;Handbook of Stem Cell Applications;2024