Affiliation:
1. Laboratory for Axon Growth and Regeneration, German Centre for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Strasse 27, 53127, Bonn, Germany
Abstract
In the adult mammalian central nervous system (CNS), neurons typically fail to regenerate their axons after injury. During development, by contrast, neurons extend axons effectively. A variety of intracellular mechanisms mediate this difference, including changes in gene expression, the ability to form a growth cone, differences in mitochondrial function/axonal transport and the efficacy of synaptic transmission. In turn, these intracellular processes are linked to extracellular differences between the developing and adult CNS. During development, the extracellular environment directs axon growth and circuit formation. In adulthood, by contrast, extracellular factors, such as myelin and the extracellular matrix, restrict axon growth. Here, we discuss whether the reactivation of developmental processes can elicit axon regeneration in the injured CNS.
Funder
Wings for Life
European Molecular Biology Organization
Deutsches Zentrum für Neurodegenerative Erkrankungen
International Foundation for Research in Paraplegia
Deutsche Forschungsgemeinschaft
Publisher
The Company of Biologists
Subject
Developmental Biology,Molecular Biology
Cited by
108 articles.
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