The class I myosin MYO1D binds to lipid and protects against colitis-Reference-Cited by-同舟云学术

The class I myosin MYO1D binds to lipid and protects against colitis

Published:2018-09-01 Issue:9 Volume:11 Page:
ISSN:1754-8411
Container-title:Disease Models & Mechanisms
language:en
Short-container-title:

Author:

McAlpine William¹,Wang Kuan-wen¹,Choi Jin Huk¹,San Miguel Miguel²,McAlpine Sarah Grace¹,Russell Jamie¹,Ludwig Sara¹,Li Xiaohong¹,Tang Miao¹,Zhan Xiaoming¹,Choi Mihwa¹,Wang Tao¹³,Bu Chun Hui¹,Murray Anne R.¹,Moresco Eva Marie Y.¹^ORCID,Turer Emre E.¹²,Beutler Bruce¹^ORCID

Affiliation:

1. Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA

2. Department of Internal Medicine, Division of Gastroenterology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505 USA

3. Quantitative Biomedical Research Center, Department of Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

Abstract

ABSTRACT Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validated mutations in Myo1d as a cause of increased susceptibility to DSS-induced colitis. MYO1D is produced in the intestinal epithelium, and the colitis phenotype is dependent on the nonhematopoietic compartment of the mouse. Moreover, MYO1D appears to couple cytoskeletal elements to lipid in an ATP-dependent manner. These findings demonstrate that MYO1D is needed to maintain epithelial integrity and protect against DSS-induced colitis.

Funder

National Institutes of Health

Crohn's and Colitis Foundation of America

Lyda Hill Foundation

Publisher

The Company of Biologists

Subject

General Biochemistry, Genetics and Molecular Biology,Immunology and Microbiology (miscellaneous),Medicine (miscellaneous),Neuroscience (miscellaneous)

Link

http://journals.biologists.com/dmm/article-pdf/doi/10.1242/dmm.035923/1863297/dmm035923.pdf

Reference36 articles.

1. Inflammatory bowel disease;Abraham;N. Engl. J. Med.,2009

2. A method and server for predicting damaging missense mutations;Adzhubei;Nat. Methods,2010

3. Rat myr 4 defines a novel subclass of myosin I: identification, distribution, localization, and mapping of calmodulin-binding sites with differential calcium sensitivity;Bahler;J. Cell Biol.,1994

4. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis;Beaudoin;PLoS Genet.,2013

5. Differential localization and dynamics of class I myosins in the enterocyte microvillus;Benesh;Mol. Biol. Cell,2010

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis;Human Molecular Genetics;2022-01-12

2. Tight Junctions in the Inflamed Gut;Tight Junctions;2022

3. Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells;ACS Omega;2021-09-16

4. Dietary Sodium Restriction Results in Tissue-Specific Changes in DNA Methylation in Humans;Hypertension;2021-08

5. Mapping Interactome Networks of FOSL1 and FOSL2 in Human Th17 Cells;2021-05-14