Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control-Reference-Cited by-同舟云学术

Neuronal death induced by endogenous extracellular ATP in retinal cholinergic neuron density control

Published:2005-06-15 Issue:12 Volume:132 Page:2873-2882
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Resta Valentina¹,Novelli Elena¹,Di Virgilio Francesco²,Galli-Resta Lucia¹

Affiliation:

1. Istituto di Neuroscienze CNR-56100 Pisa, Italy

2. Department of Experimental and Diagnostic Medicine, Section of General Pathology, and Interdisciplinary Center for the Study of Inflammation (ICSI),University of Ferrara, 44100 Ferrara, Italy

Abstract

The precise assembly of neuronal circuits requires that the correct number of pre- and postsynaptic neurons form synaptic connections. Neuronal cell number is thus tightly controlled by cell death during development. Investigating the regulation of cell number in the retina we found an ATP gated mechanism of neuronal death control. By degrading endogenous extracellular ATP or blocking the P2X7 ATP receptors we found that endogenous extracellular ATP triggers the death of retinal cholinergic neurons during normal development. ATP-induced death eliminates cholinergic cells too close to one another, thereby controlling the total number, the local density and the regular spacing of these neurons.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/132/12/2873/1508787/2873.pdf

Reference55 articles.

1. Alexiades, M. R. and Cepko, C. (1996). Quantitative analysis of proliferation and cell cycle length during development of the rat retina. Dev. Dyn.205,293-307.

2. Bodin, P. and Burnstock, G. (2001). Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular. J. Cardiovasc. Pharmacol.38,900-908.

3. Cook, J. E. and Chalupa, L. M. (2000). Retinal mosaics: new insights into an old concept. Trends Neurosci.23,26-34.

4. Davies, A. M. (2003). Regulation of neuronal survival and death by extracellular signals during development. EMBO J.22,2537-2545.

5. de la Rosa, E. J. and de Pablo, F. (2000). Cell death in early neural development: beyond the neurotrophic theory. Trends Neurosci.23,454-458.

Cited by 64 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina;Purinergic Signalling;2023-12-27

2. Homeostatic plasticity in the retina;Progress in Retinal and Eye Research;2023-05

3. Retinal self-organization: a model of retinal ganglion cells and starburst amacrine cells mosaic formation;Open Biology;2023-04

4. P2X7 Is Involved in the Mouse Retinal Degeneration via the Coordinated Actions in Different Retinal Cell Types;Antioxidants;2023-01-06

5. Involvement of the Purinergic System in Cell Death in Models of Retinopathies;Purinergic System;2022-09-07