Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors

Author:

Längst Gernot1,Becker Peter B.2

Affiliation:

1. Adolf-Butenandt-Institut, Schillerstraße 44, München 80336, Germany

2. Author for correspondence (e-mail: Peter.Becker@mol-bio.med.uni-muenchen.de )

Abstract

ATP-dependent chromatin-remodeling machines of the SWI/SNF family are involved in many cellular processes in eukaryotic nuclei, such as transcription, replication, repair and recombination. Remodeling factors driven by the ATPase ISWI make up a subgroup of this family that exhibits defined mechanistic and functional characteristics. ISWI-induced nucleosome mobility endows nucleosomal arrays with dynamic properties and recent results suggest that ISWI-type remodelers have diverse functions that range from transcriptional regulation to chromatin assembly and maintenance of chromosome structure.

Publisher

The Company of Biologists

Subject

Cell Biology

Reference76 articles.

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