PKB/Akt

Author:

Lawlor Margaret A.1,Alessi Dario R.2

Affiliation:

1. MRC Protein Phosphorylation Unit, Department of Life Sciences, University of Dundee, Dundee DD1 5EH, UK

2. Author for correspondence (e-mail: d.r.alessi@dundee.ac.uk)

Abstract

The serine/threonine protein kinase PKB (also known as Akt) is thought to be a key mediator of signal transduction processes. The identification of PKB substrates and the role PKB phosphorylation plays in regulating these molecules have been a major focus of research in recent years. A recently developed motif-profile scoring algorithm that can be used to scan the genome for potential PKB substrates is therefore a useful tool, although additional considerations, such as the evolutionary conservation of the phosphorylation site, must also be taken into account. Recent evidence indicates that PKB plays a key role in cancer progression by stimulating cell proliferation and inhibiting apoptosis and is also probably a key mediator of insulin signalling. These findings indicate that PKB is likely to be a hot drug target for the treatment of cancer, diabetes and stroke. There are, however, a number of pitfalls of methodologies currently employed to study PKB function, and therefore caution should be used in interpretation of such experiments.

Publisher

The Company of Biologists

Subject

Cell Biology

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