Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues-Reference-Cited by-同舟云学术

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues

Published:2004-07-01 Issue:13 Volume:131 Page:3047-3055
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Cases Sylvaine¹,Zhou Ping¹,Shillingford Jonathan M.²,Wiseman Bryony S.³,Fish Jo Dee¹,Angle Christina S.¹,Hennighausen Lothar²,Werb Zena⁴³,Farese Robert V.¹⁴⁵

Affiliation:

1. Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94141-1900,USA

2. Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892,USA

3. Department of Anatomy, University of California, San Francisco, CA 94143,USA

4. Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA

5. Department of Medicine, University of California, San Francisco, CA 94143,USA

Abstract

Mammary gland development is a complex process that is dependent on interactions between the developing mammary epithelium and the surrounding stromal tissues. We show that mice lacking the triglyceride synthesis enzyme acyl CoA:diacylglycerol transferase 1 (DGAT1) have impaired mammary gland development, characterized by decreased epithelial proliferation and alveolar development, and reduced expression of markers of functional differentiation. Transplantation studies demonstrate that the impaired development results from a deficiency of DGAT1 in both the stromal and epithelial tissues. Our findings are the first to link defects in stromal lipid metabolism to impaired mammary gland development.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/131/13/3047/1544309/3047.pdf

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