The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions

Author:

Herman M.A.1,Horvitz H.R.1

Affiliation:

1. Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

The generation and orientation of cellular and organismic polarity are fundamental aspects of development. Mutations in the gene lin-44 of the nematode Caenorhabditis elegans reverse both the relative positions of specific sister cells and the apparent polarities of these cells. Thus, lin-44 mutants appear to generate polar cells but to misorient these cells along the body axis of the animal. We postulate that lin-44 acts to specify the orientation of polar cells.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

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