A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2–p53 axis
Author:
Affiliation:
1. Massachusetts Institute of Technology 1 Department of Biology , , Cambridge, MA 02139 , USA
2. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology 2 , Cambridge, MA 02139 , USA
Abstract
Funder
National Institutes of Health
National Institute of General Medical Sciences
Pew Charitable Trusts
National Cancer Institute
Massachusetts Institute of Technology
Publisher
The Company of Biologists
Link
https://journals.biologists.com/dmm/article-pdf/doi/10.1242/dmm.050356/3378965/dmm050356.pdf
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3. Snrpb, the CCMS gene, is required in neural crest cells for proper splicing and craniofacial morphogenesis;Alam;Dis. Model. Mech.,2022
4. p53 is activated in response to disruption of the pre-mRNA splicing machinery;Allende-Vega;Oncogene,2013
5. Mutant PRPF8 causes widespread splicing changes in spliceosome components in retinitis pigmentosa patient iPSC-derived RPE cells;Arzalluz-Luque;Front. Neurosci.,2021
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