1. University of Oxford 1 Department of Biochemistry , , South Parks Road, Oxford OX1 3QU , UK
2. MRC London Institute of Medical Sciences, Hammersmith Hospital Campus 2 , Du Cane Road, London W12 0NN , UK
3. Institute of Clinical Sciences, Imperial College London 3 , Du Cane Road, London W12 0NN , UK
4. Virginia Tech 4 Department of Biological Sciences , , Blacksburg, VA 24061 , USA