1. Laboratory of Signal Transduction, National Institute of Environmental Health Science, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
2. Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC 27710, USA
3. The Office of Clinical Research, National Institute of Environmental Health Science, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
4. Department of Medicine, Duke University Medical Center, Durham, NC 27710,USA
5. Department of Biochemistry, Duke University Medical Center, Durham, NC 27710,USA