giant nucleiis essential in the cell cycle transition from meiosis to mitosis-Reference-Cited by-同舟云学术

giant nucleiis essential in the cell cycle transition from meiosis to mitosis

Published:2003-07-01 Issue:13 Volume:130 Page:2997-3005
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Renault Andrew D.¹²,Zhang Xiao-Hua¹,Alphey Luke S.¹,Frenz Lisa M.³,Glover David M.⁴,Saunders Robert D. C.⁵,Axton J. Myles¹

Affiliation:

1. Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK

2. Present address: Skirball Institute, Developmental Genetics Program, New York University Medical Center, 540 First Avenue, NY 10016, USA

3. Polgen Division, Cyclacel, Babraham Bioincubator 405, Babraham Institute,Babraham, Cambridgeshire CB2 4AT, UK

4. Department of Genetics, University of Cambridge, Downing Street, Cambridge,CB2 3EH, UK

5. Department of Biological Sciences, The Open University, Walton Hall, Milton Keynes, MK7 6AA, UK

Abstract

At the transition from meiosis to cleavage mitoses, Drosophilarequires the cell cycle regulators encoded by the genes, giant nuclei(gnu), plutonium (plu) and pan gu(png). Embryos lacking Gnu protein undergo DNA replication and centrosome proliferation without chromosome condensation or mitotic segregation. We have identified the gnu gene encoding a novel phosphoprotein dephosphorylated by Protein phosphatase 1 at egg activation. Gnu is normally expressed in the nurse cells and oocyte of the ovary and is degraded during the embryonic cleavage mitoses. Ovarian death and sterility result from gnu gain of function. gnu function requires the activity of pan gu and plu.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/130/13/2997/1143632/2997.pdf

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