Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection-Reference-Cited by-同舟云学术

Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection

Published:2004-03-15 Issue:6 Volume:131 Page:1377-1388
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Wang Song S.¹²³,Lewcock Joseph W.¹²,Feinstein Paul⁴,Mombaerts Peter⁴,Reed Randall R.¹²³

Affiliation:

1. The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 818, Baltimore, MD 21205, USA

2. Department of Molecular Biology and Genetics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, PCTB 818, Baltimore, MD 21205,USA

3. Department of Neuroscience, The Johns Hopkins University School of Medicine,725 North Wolfe Street, PCTB 818, Baltimore, MD 21205, USA

4. The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA

Abstract

The mammalian Olf1/EBF (O/E) family of repeated helix-loop-helix (rHLH)transcription factors has been implicated in olfactory system gene regulation,nervous system development and B-cell differentiation. Ebf(O/E1) mutant animals showed defects in B-cell lineage and brain regions where it is the only O/E family member expressed, but the olfactory epithelium appeared unaffected and olfactory marker expression was grossly normal in these animals. In order to further study the mammalian O/E proteins,we disrupted O/E2 and O/E3 genes in mouse and placed tau-lacZ and tau-GFP reporter genes under the control of the respective endogenous O/E promoters. Mice mutant for each of these genes display reduced viability and other gene-specific phenotypes. Interestingly, both O/E2 and O/E3 knockout mice as well as O/E2/O/E3 double heterozygous animals share a common phenotype:olfactory neurons (ORN) fail to project to dorsal olfactory bulb. We suggest that a decreased dose of O/E protein may alter expression of O/E target genes and underlie the ORN projection defect.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/131/6/1377/1507586/1377.pdf

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